Inflammation IVD Raw Materials

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Last update: 2019-10-30 19:55
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Human CRP


Background:

C-reactive protein was first discovered in 1930. It is an acute reaction protein that can react to pneumococcal C polusacharide and become a compound. It is compounded mostly in the liver cells. The concentration of CRP in a normal adult is usually less than 10mg/L, Once the organism is stimulated by inflammation or tissue trauma, liver will immediately produce a lot of CRP, especially when the organism is infected by virus, about 96% patient’s body increases the level of CRP in a rapid speed. CRP is a very sensitive, non-specific mark of systemic inflammation, tissue trauma and infection. Prospective epidemiological study shows that the level of CRP is a strong, independent and predicable risk factor of people who have the disease of myocardial infarction, stroke, peripheral artery disease, no obvious cardiovascular disease, acute coronary syndrome and stable coronary artery disease (CAD). Besides, CRP is not very sensitive to the external factor such as age, gender or anemia. It has more advantages than other acute phase reactants in differentiating infantile pneumonia infection types.


Clinical Significance:

1. The normal reference value of CRP is no more than 10mg/L, and the degree of increase of CRP reflects the size or activity of inflammatory tissue. In the case of acute inflammation and infection, CRP has a good correlation with disease activity.

2. A CRP value of 10-50mg/L indicates mild inflammation, such as local bacterial infections (such as cystitis, bronchitis, abscess), surgery and accidental trauma, myocardial infarction, deep vein thrombosis, inactive connective tissue disease, many malignancies, and most viral infections

3. A CRP value of about 100mg/L can indicate a serious disease and the presence of bacterial infection.


Parameters:

Test

Description

Type

Item No

Source

Application

Recommend to use for

CRP

CRP Antigen

Natural Antigen

GHCA070-1

Human

EIA, LF

/

CRP 6G5

mAb

GHMA057-1

mouse

EIA, LF

Coating/Labeling

CRP 7G9

mAb

GHMA057-2

mouse

EIA, LF

Coating/Labeling




PCT


Background:

PCT is a protein that is elevated in plasma during severe bacterial, fungal, and parasitic infections, as well as sepsis and multiple organ failure.

PCT does not increase with autoimmunity, allergy, or viral infection.

Limited local bacterial infection, mild infection and chronic inflammation will not lead to its elevation.

Bacterial endotoxin plays an important role in the induction process.


Clinical significance:

PCT reflects the level of systemic inflammatory response.

Factors that affect PCT levels include the size and type of organ being infected, the type of bacteria, the level of inflammation, and the state of the immune response.

In addition, PCT can only be detected in a small number of patients 1 to 4 days after major surgery.

Elevated PCT levels are seen in severe shock, systemic inflammatory response syndrome (SIRS), and multiple organ dysfunction syndrome (MODS), even without bacterial infection or bacterial lesions.

However, in these cases, PCT levels are usually lower than in patients with bacterial lesions.

Release of cytokines or bacterial translocation from the gut may induce induction.


Product parameters:

The specificity is very good, the cutoff value is 0.5ng-2ng, ang-10ng, greater than 10ng, our background is very clean, 0.0.5ng-0.5ng, the low value does not fluctuate.

Test

Description

Type

Item No

Source

Application

Recommend to use for

PCT

PCT Antigen

rAg

GHCA071-1

E.coli

EIA, LF

/

PCT-4D2

mAb

GHMA052-4

mouse

EIA, LF

Coating

PCT-12C5

mAb

GHMA052-1

mouse

EIA, LF

Labeling


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